MOTS-C

MOTS-C is a mitochondrial-derived peptide encoded within the mitochondrial genome, supplied here in a 10mg quantity for laboratory research use only. Laboratory research has explored the interaction of MOTS-C with mitochondrial-signaling and metabolic pathways, including AMPK signaling and mitochondrial-to-nuclear retrograde communication. Advanced Peptide Institute MOTS-C is supplied at 99% purity, verified through independent third-party testing. For additional information, click here. This compound is intended for research use only, and its applications outside of laboratory settings have not been established.

MOTS-C is a mitochondrial-derived peptide encoded within the mitochondrial genome, supplied here in a 10mg quantity for laboratory research use only. Laboratory research has explored MOTS-C’s interaction with mitochondrial-signaling and metabolic pathways. Advanced Peptide Institute MOTS-C is supplied at 99% purity, verified through independent third-party testing.

What is MOTS-C?

MOTS-C is a short, 16-amino-acid peptide sequence encoded within the mitochondrial 12S rRNA gene region, rather than the nuclear genome, placing it within a distinct class known as mitochondrial-derived peptides. Researchers examine MOTS-C in the context of AMPK (AMP-activated protein kinase) signaling, a pathway central to cellular energy regulation, and in the context of mitochondrial-to-nuclear retrograde signaling, the communication network linking mitochondria to nuclear gene expression. Published research has also explored MOTS-C’s interaction with folate-mediated one-carbon metabolic pathways, which are connected to nucleotide synthesis and cellular stress-response signaling. Its designation, MOTS-C, denotes its identification as a Mitochondrial Open Reading Frame of the 12S rRNA-c region, distinguishing it from peptides translated from the conventional nuclear genome, a naming convention shared by several other mitochondrial-derived peptides identified in the same research literature. This 10mg format is supplied strictly for laboratory and in vitro research use, not for human or veterinary use.

Research Applications

Laboratory researchers studying mitochondrial bioenergetics frequently incorporate MOTS-C into in vitro models to examine AMPK-pathway activity and downstream metabolic-signaling responses. Because MOTS-C originates from mitochondrial DNA rather than the nuclear genome, it is also a subject of research comparing mitochondrial-encoded and nuclear-encoded signaling peptides. Research contexts examining cellular stress-response pathways and one-carbon metabolism make use of MOTS-C to explore its documented interaction with these signaling networks. Additional research applications include the study of mitochondrial-nuclear communication pathways more broadly, an active area of mitochondrial genomics research. Some in vitro protocols also examine MOTS-C alongside other mitochondrial-derived peptides identified within the same research literature, comparing pathway interactions across this peptide family. All work involving MOTS-C at Advanced Peptide Institute is intended solely for laboratory and in vitro research settings.

Purity & Third-Party Testing

Advanced Peptide Institute MOTS-C (10mg) is manufactured to a minimum of 99% purity. Every batch is verified by independent third-party testing using HPLC (high-performance liquid chromatography) and mass spectrometry to confirm both identity and purity. Each Certificate of Analysis lists the specific batch number, testing date, and confirmed purity percentage. A Certificate of Analysis is published for every batch at advancedpeptideinstitute.com/certificate-of-analysis, letting researchers cross-reference results against the lot number on the product label before use in a laboratory protocol.

Storage & Handling

Store lyophilized compound at −20°C for long-term stability. Refrigerate at 2–8°C after reconstitution and use within 4–6 weeks. Minimize freeze-thaw cycling, shield from direct light, and reseal promptly between laboratory uses. Reconstituted solution should be kept in an opaque or amber container to further limit light exposure, and labeled with the reconstitution date so the 4–6 week usable window is tracked accurately.

Frequently Asked Questions

What is MOTS-C?

MOTS-C (10mg) is a mitochondrial-derived peptide studied in laboratory research for its interaction with mitochondrial and metabolic-signaling pathways.

What purity is Advanced Peptide Institute MOTS-C?

Advanced Peptide Institute MOTS-C is supplied at 99% purity, verified by independent third-party HPLC testing and mass spectrometry. A Certificate of Analysis is available for every batch at https://advancedpeptideinstitute.com/certificate-of-analysis/.

How should MOTS-C be stored?

Store lyophilised compound at −20°C for long-term stability. Refrigerate at 2–8°C after reconstitution and use within 4–6 weeks.

Published laboratory research on MOTS-C is indexed on PubMed.

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For research use only. Not for human consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.